Liiketoiminta ja teollisuus > Tutkimus- ja laboratoriotuotteet
Tuotenro: 247-OKCD00653
Koko: 96 Wells
Toimittaja: Gentaur
Jakaa:
Description of target: Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:8034696). Does not bind acetyl-CoA and does not have histone acetyltransferase activity.By similarity
 <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:O60502 (OGA_HUMAN)1 Publication
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.2"Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol."_x005F_x005F_x000D_Dong D.-L., Hart G.W._x005F_x005F_x000D_J. Biol. Chem. 269:19321-19330(1994) [PubMed] [Europe PMC] [Abstract]Cited for: BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, ENZYME REGULATION, TISSUE SPECIFICITY. Isoform 2: Lacks enzyme activity.1 Publication
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.4"Location and characterization of the O-GlcNAcase active site."_x005F_x005F_x000D_Toleman C., Paterson A.J., Kudlow J.E._x005F_x005F_x000D_Biochim. Biophys. Acta 1760:829-839(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION OF ISOFORMS 2 AND 3, LACK OF CATALYTIC ACTIVITY OF ISOFORMS 2 AND 3. Isoform 3: Lacks enzyme activity.1 Publication
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.4"Location and characterization of the O-GlcNAcase active site."_x005F_x005F_x000D_Toleman C., Paterson A.J., Kudlow J.E._x005F_x005F_x000D_Biochim. Biophys. Acta 1760:829-839(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION OF ISOFORMS 2 AND 3, LACK OF CATALYTIC ACTIVITY OF ISOFORMS 2 AND 3. ;Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.55 ng/mL
